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Background: COPD guidelines report that systemic corticosteroids are preferred over inhaled corticosteroids in the treatment of exacerbations, but the inhaled route is considered to be an optionfor the short-term. The authors suggest that a second inhalation is preferable to use this short-term option. Procedure: 30 subjects with COPD were randomized to placebo, 10 mg intravenously (20 micrograms), or 1 mg intravenously (10 micrograms), and were monitored for six weeks. The second inhalation was performed by a physician, steroid body meaning in tamil. Results: After 6 weeks, both the first and second inhalations demonstrated reduction in all parameters of the COPD patient (age in weeks 0-3, mean age: 47 +/- 13 years; height 2.2 +/- 0.3 years; body weight in pounds 17.2 - 26.1, mean weight 32.7 +/- 3.0 kg). The reduction in the lung function was greatest when the second inhalation occurred early in the exacerbation (mean change in the maximum work capacity of the lung: -18%; duration of exacerbation: 7 +/- 2 days [8-14% longer]) for the oral, but not the intravenous (vs 1 - 8% difference; mean duration between first and second inhalations : 2.0 +/- 2.6 days [13-27%] for the oral, and 3.2 +/- 3.2 days [38-50% longer] for the IV). As expected, the first-time treatment with 2 mg/kg (versus 10 mg/kg) showed a greater increase in the second-time treatment group (3, corticosteroids otc pills.7 +/- 2, corticosteroids otc pills.5), corticosteroids otc pills. Conclusion: The first inhalation was a good way to maintain a stable COPD patient. The second inhalation was shown to be an acceptable alternative, pills otc corticosteroids. Key Points: The present study demonstrated that both the oral and intravenous routes can be used to treat COPD exacerbations for a short time, but an additional inhalation (involving 2 mg/kg) is preferred.


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